SWEETzenn

Notifications

Product	INCI	Description of Actives	Mode of Action	Benefits	Use Level (WT%)	Test
AWC-01	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Acetyl sh-Tripeptide-1 Amide	FGF-1 (Fibroblast Growth Factor-1) biomimetic peptide	Stimulates fibroblast proliferation and ECM synthesis (Collagen, Elastin, Hyaluronic Acid, Fibronectin) via FGFR activation	Increases skin elasticity, wrinkle improvement, regeneration	1~2%	● In-vitro / ● Ex-vivo
AWC-02	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Acetyl sh-Tripeptide-3 Amide	EGF (Epidermal Growth Factor) biomimetic peptide	Stimulates keratinocyte proliferation and ECM synthesis via EGFR activation	Skin regeneration, wrinkle reduction, renewal cycle improvement	1~2%	● In-vitro / ● Ex-vivo / ● UR
AWC-03	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Acetyl Tripeptide-54 Amide	Adiponectin (APN) biomimetic peptide	Promotes fibroblast activation and hydration, reinforces dermal barrier	Strengthens skin barrier, deep hydration, reduces water loss	1~5%	● In-vitro / ● UR
AWC-04	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Acetyl Tetrapeptide-18	p53 biomimetic peptide	Activates p53 to remove senescent (“zombie”) cells	Anti-aging, cellular renewal, texture improvement	1~5%	● In-vitro
AWC-05	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Acetyl D-Threonyl D-Valyl D-Glutamyl D-Phenylalanine	Retinoic acid receptor (RARs) biomimetic peptide	Activates RARs, promoting effects similar to retinol	Wrinkle reduction, tone & texture improvement, regeneration	1~5%	● In-vitro / ● Ex-vivo
AWC-06	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Acetyl D-Lysyl D-Asparaginyl D-Leucine	VAMP2 (Synaptobrevin 2) biomimetic peptide	Relaxes facial muscle contraction; mimics botulinum toxin activity	Reduces expression lines, smooths deep wrinkles	1~5%	● In-vitro / ● UR

Product	INCI	Description of Actives	Mode of Action	Benefits	Use Level (WT%)	Test
AWT-01	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Acetyl sh-Tripeptide-1 Amide (and) Acetyl sh-Tripeptide-3 Amide	FGF-1 biomimetic peptide EGF biomimetic peptide	- Stimulates fibroblast proliferation and dermal ECM production (Collagen, Elastin, Hyaluronic Acid, Fibronectin) via FGFR activation - Stimulates epidermal keratinocytes and ECM synthesis via EGFR activation	- Increases skin elasticity & resiliency - Wrinkle improvement - Skin regeneration - Skin renewal cycle improvement	1~2%	-
AWT-01	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Acetyl Tripeptide-54 Amide (and) Acetyl Tripeptide-74 Amide (and) Acetyl sh-Tripeptide-1 Amide (and) Acetyl sh-Tripeptide-3 Amide	Adiponectin biomimetic peptide NF-κB antagonist peptide FGF-1 & EGF biomimetic peptides	- Stimulates keratinocytes in the epidermal layer, reinforcing skin barrier proteins (filaggrin, loricrin, involucrin) - Reduces inflammatory responses by inhibiting NF-κB - Stimulates fibroblast proliferation and ECM synthesis via FGFR & EGFR activation	- Strengthens skin barrier - Deep skin hydration - Reduces transepidermal water loss - Increases skin elasticity - Wrinkle improvement - Skin renewal enhancement	1~5%	-

Product	INCI	Description of Actives	Mode of Action	Benefits	Use Level (WT%)	Test
ISS-01	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Acetyl sh-Tripeptide-4 Amide	CD99 biomimetic peptide	- Inhibits inflammatory cytokine expression via CD99 activation - Controls sebum secretion by p53 regulation - Improves HFS (Hand-Foot Syndrome)	- Anti-inflammatory - Soothes acne-prone & sensitive skin - Decreases sebum production - Relieves HFS symptoms - Senolytic effect	1~5%	● In-vitro / ● Ex-vivo / ● Pilot Trial(HFS)
ISS-02	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Acetyl Tripeptide-74 Amide	NF-κB antagonist biomimetic peptide	- Suppresses inflammation by inhibiting NF-κB pathway	- Soothes sensitive skin - Reduces redness and irritation - Improves elasticity	1~5%	● In-vitro
ISS-03	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Acetyl D-Glutamyl D-Valyl D-Phenylalanyl D-Glycine	Vitamin D biomimetic peptide	- Activates vitamin D receptor (VDR) to promote antioxidant and anti-inflammatory responses	- Antioxidant - Sebum control - Skin renewal normalization	1~5%	● In-vitro
ISS-04	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Tripeptide-81	AHR (Aryl Hydrocarbon Receptor) antagonist peptide	- Reduces inflammation by blocking AHR transcriptional activity	- Soothes skin - Reduces inflammation and irritation	1~5%	● In-vitro

Product	INCI	Description of Actives	Mode of Action	Benefits	Use Level (WT%)	Test
PDSL-01	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Acetyl Tripeptide-53 Amide	Sfrp5 (Secreted Frizzled-Related Protein 5) biomimetic peptide	- Inhibits Wnt pathway signaling to reduce melanogenesis	- Reduces melanin production - Brightens skin tone - Improves freckles and dark spots	1~5%	● In-vitro
PDSL-02	Water (and) 1,2-Hexanediol (and) Caprylyl Glycol (and) Acetyl Tripeptide-57 Amide	MITF (Microphthalmia-Associated Transcription Factor) antagonist peptide	- Suppresses MITF transcription to block melanin formation	- Anti-pigmentation - Brightens dull skin	1~5%	● In-vitro

Product	INCI	Description of Actives	Mode of Action	Benefits	Use Level (WT%)
siRNA-01	S-RNA-5	Matrix Metalloproteinase-1 (MMP-1) silencing RNA	– Inhibits the expression of MMP-1, an enzyme that degrades collagen in the dermal extracellular matrix	– Increases skin elasticity & firmness – Wrinkle improvement – Skin regeneration	1~5%
siRNA-02	S-RNA-5	Hyaluronidase silencing RNA	– Suppresses the expression of hyaluronidase, an enzyme that breaks down hyaluronic acid in the skin	– Soothes skin – Increases elasticity – Skin regeneration	1~5%
siRNA-03	S-RNA-5	Tyrosinase silencing RNA	– Inhibits melanin production by silencing the tyrosinase gene, a key enzyme in pigmentation	– Anti-pigmentation – Brightens skin tone	1~5%
siRNA-04	S-RNA-5	Androgen receptor-1 (AR-1) silencing RNA	– Reduces hair loss by silencing the AR-1 gene, which triggers follicle miniaturization via DHT (dihydrotestosterone)	– Reduces genetic hair loss (Androgenic alopecia)	1~5%
siRNA-05	S-RNA-5	5α-Reductase silencing RNA	– Inhibits 5α-reductase enzyme that converts testosterone into DHT, helping prevent hair follicle miniaturization	– Reduces genetic hair loss (Androgenic alopecia)	1~5%